Roflumilast, which is an anti-inflammatory medicine called phosphodiestarase 4 inhibitor. Roflumilast reduces the activity of phosphodiestarase 4, a protein occurring naturally in body cells. In the present work three simple, economical, precise and accurate UV spectrophotometric methods have been developed for the estimation of roflumilast in bulk and pharmaceutical formulation. Method A is absorption maxima method in which λ max was found to be 250 nm. Method B is area under the curve (AUC) in which area in the wavelength range of 241 nm-259 nm was selected for analysis of roflumilast. Linearity was observed in the concentration range 5-30 μg/ml (r2 =0.997) for two methods. The % assay for the marketed formulation for absorption maxima and area under the curve method was found to be 99.25 % and 99.3434 % respectively. The methods were validated with respect to linearity, precision and accuracy studies. Recovery studies for absorption maxima and area under the curve was found to be 99.32%-100.69% respectively. The methods were found to be simple, precise and accurate and can be employed for routine quality control analysis of roflumilast in bulk as well as from its dosage form.
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